Physiological impacts of diet

"Suggests iron deterioration of AD brain"

Iron Can Accelerate the Conjugation Reaction between Abeta 1-40
Peptide and MDA
Park, Yong-Hoon ; Jung, Jai-Yun ; Son, Il-Hong
Molecular & cellular toxicology
Volume 5, Issue 2,  June 2009, pp.108-112
The Korean Society of Toxicogenomics and Toxicoproteomics

Abstract Alzheimer’s disease(AD) is a neurodegenerative disorder
characterized pathologically by senile plaques, neurofibrillary
tangles, and synapse loss.
Especially, extracellular beta-amyloid (Abeta) deposition is a
major pathological hallmark of Alzheimer’s disease (AD).
In AD senile plaques, high level of iron and car-bonylated Abeta
were detected.
Iron has a Lewis acid property which can increase the
electrophilicity of carbonyls, which may react catalytically with
nucleophiles, such as amines.
Hence, this study investigated whether or not iron could promote
the carbonylation of amine with malondialdehyde (MDA) in the
physiological condition.
As the basic study, we examined that iron might promote the
conjugation reaction between propylamine, monoamine molecule and
MDA in the physiological condition.
As the concentration of iron increased, the fluorescence intensity
produced from the conjugation reaction increased in a dose-dependent
manner.
Instead of propylamine, we applied the same reaction condition to
Abeta 1-40 peptide, one of major components founded in AD senile
plaques for the conjugation reaction.
As the result, the fluorescence intensity produced from the
conjugation reaction between Abeta 1-40 peptide and MDA showed
the similar trend to that of the reaction used with propylamine.
This study suggests that iron can accelerate the conjugation
reaction of MDA to Abeta 1-40 peptide and play an another important
role in deterioration of AD brain.

Keywords Beta-amyloid;  Iron;  Conjugation;  Malondialdehyde;
Senile plaque;  Alzheimer’s disease

ISSN : 1738-642x

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